{"id":1525,"date":"2018-07-30T19:13:50","date_gmt":"2018-07-30T19:13:50","guid":{"rendered":"https:\/\/odan.odanlabdev.ca\/asmacure\/approche-scientifique\/"},"modified":"2018-09-13T02:34:17","modified_gmt":"2018-09-13T02:34:17","slug":"approche-scientifique","status":"publish","type":"page","link":"https:\/\/odanlab.com\/fr\/approche-scientifique\/","title":{"rendered":"Approche scientifique"},"content":{"rendered":"<div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\"  style='background-color: rgba(255,255,255,0);background-position: center center;background-repeat: no-repeat;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;'><div class=\"fusion-builder-row fusion-row \"><div  class=\"fusion-layout-column fusion_builder_column fusion_builder_column_1_1 fusion-builder-column-0 fusion-one-full fusion-column-first fusion-column-last 1_1\"  style='margin-top:0px;margin-bottom:20px;'><div class=\"fusion-column-wrapper\" style=\"padding: 0px 0px 0px 0px;background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;\"   data-bg-url=\"\"><div class=\"fusion-text\"><p>L&#8217;approche scientifique d&#8217;Asmacure dans l\u2019utilisation des agonistes de r\u00e9cepteurs d&#8217;ac\u00e9tylcholine nicotiniques pour le traitement des maladies inflammatoires est bas\u00e9e sur les premi\u00e8res observations cliniques selon lesquelles les fumeurs ont une incidence plus faible de plusieurs maladies inflammatoires, y compris la pneumopathie d&#8217;hypersensibilit\u00e9. Apr\u00e8s avoir men\u00e9 des recherches approfondies sur la pathologie de cette maladie, le Dr Cormier et son \u00e9quipe ont d\u00e9montr\u00e9 que l&#8217;activation de ces r\u00e9cepteurs par la nicotine avait un effet inhibiteur marqu\u00e9 sur l&#8217;inflammation pulmonaire chez un mod\u00e8le murin de HP parce que la nicotine cr\u00e9e une d\u00e9pendance et pr\u00e9sente donc un potentiel th\u00e9rapeutique tr\u00e8s limit\u00e9, les chercheurs ont test\u00e9 le dim\u00e9thylph\u00e9nylpip\u00e9razinium (DMPP), l&#8217;un des nombreux agonistes nicotiniques de sources naturelles et synth\u00e9tiques disponibles dans le commerce qui ne devrait pas traverser la barri\u00e8re h\u00e9mato-enc\u00e9phalique et ne devrait donc pas avoir de propri\u00e9t\u00e9s addictives.<\/p>\n<p>Simultan\u00e9ment avec l&#8217;\u00e9tude sur HP, les chercheurs ont d\u00e9couvert que les r\u00e9cepteurs nicotiniques \u00e9taient pr\u00e9sents sur les \u00e9osinophiles et les cellules musculaires lisses des voies respiratoires, deux composants importants impliqu\u00e9s dans la pathologie de l&#8217;asthme. L&#8217;asthme a ensuite \u00e9t\u00e9 choisi comme cible initiale pour le d\u00e9veloppement de futurs m\u00e9dicaments.<br \/>\nAfin de g\u00e9n\u00e9rer de nouveaux compos\u00e9s pour le d\u00e9veloppement pharmaceutique, une s\u00e9rie d&#8217;analogues ont ensuite \u00e9t\u00e9 synth\u00e9tis\u00e9s conduisant \u00e0 la s\u00e9lection de l&#8217;ASM-024 en tant que compos\u00e9 principal d&#8217;Asmacure.<\/p>\n<p>Des \u00e9tudes de preuve de concept ont \u00e9t\u00e9 men\u00e9es avec le DMPP et diff\u00e9rents nouveaux analogues. Ces compos\u00e9s bloquaient la transmigration des \u00e9osinophiles in vitro, exer\u00e7aient des effets relaxants ex vivo sur les cellules musculaires lisses des voies respiratoires chez la souris, le chien et l&#8217;homme et avaient des effets anti-inflammatoires et bronchoprotecteurs dans des mod\u00e8les animaux d&#8217;asthme.<\/p>\n<\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"jetpack_post_was_ever_published":false,"footnotes":""},"class_list":["post-1525","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.0 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Approche scientifique - Odan Laboratories Ltd.<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/odanlab.com\/fr\/asmacure__trashed\/approche-scientifique\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Approche scientifique - Odan Laboratories Ltd.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/odanlab.com\/fr\/asmacure__trashed\/approche-scientifique\/\" \/>\n<meta property=\"og:site_name\" content=\"Odan Laboratories Ltd.\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/odanlab\/\" \/>\n<meta property=\"article:modified_time\" content=\"2018-09-13T02:34:17+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data1\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/odanlab.com\/fr\/asmacure__trashed\/approche-scientifique\/\",\"url\":\"https:\/\/odanlab.com\/fr\/asmacure__trashed\/approche-scientifique\/\",\"name\":\"Approche scientifique - Odan Laboratories Ltd.\",\"isPartOf\":{\"@id\":\"https:\/\/odanlab.com\/#website\"},\"datePublished\":\"2018-07-30T19:13:50+00:00\",\"dateModified\":\"2018-09-13T02:34:17+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/odanlab.com\/fr\/asmacure__trashed\/approche-scientifique\/#breadcrumb\"},\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/odanlab.com\/fr\/asmacure__trashed\/approche-scientifique\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/odanlab.com\/fr\/asmacure__trashed\/approche-scientifique\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/odanlab.com\/fr\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Approche scientifique\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/odanlab.com\/#website\",\"url\":\"https:\/\/odanlab.com\/\",\"name\":\"Odan Laboratories Ltd.\",\"description\":\"The Leader in Specialty Generic Pharmaceutical Products\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/odanlab.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"fr-FR\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Approche scientifique - Odan Laboratories Ltd.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/odanlab.com\/fr\/asmacure__trashed\/approche-scientifique\/","og_locale":"fr_FR","og_type":"article","og_title":"Approche scientifique - Odan Laboratories Ltd.","og_url":"https:\/\/odanlab.com\/fr\/asmacure__trashed\/approche-scientifique\/","og_site_name":"Odan Laboratories Ltd.","article_publisher":"https:\/\/www.facebook.com\/odanlab\/","article_modified_time":"2018-09-13T02:34:17+00:00","twitter_card":"summary_large_image","twitter_misc":{"Dur\u00e9e de lecture estim\u00e9e":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/odanlab.com\/fr\/asmacure__trashed\/approche-scientifique\/","url":"https:\/\/odanlab.com\/fr\/asmacure__trashed\/approche-scientifique\/","name":"Approche scientifique - Odan Laboratories Ltd.","isPartOf":{"@id":"https:\/\/odanlab.com\/#website"},"datePublished":"2018-07-30T19:13:50+00:00","dateModified":"2018-09-13T02:34:17+00:00","breadcrumb":{"@id":"https:\/\/odanlab.com\/fr\/asmacure__trashed\/approche-scientifique\/#breadcrumb"},"inLanguage":"fr-FR","potentialAction":[{"@type":"ReadAction","target":["https:\/\/odanlab.com\/fr\/asmacure__trashed\/approche-scientifique\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/odanlab.com\/fr\/asmacure__trashed\/approche-scientifique\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/odanlab.com\/fr\/"},{"@type":"ListItem","position":2,"name":"Approche scientifique"}]},{"@type":"WebSite","@id":"https:\/\/odanlab.com\/#website","url":"https:\/\/odanlab.com\/","name":"Odan Laboratories Ltd.","description":"The Leader in Specialty Generic Pharmaceutical Products","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/odanlab.com\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"fr-FR"}]}},"jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/Pahxdx-oB","_links":{"self":[{"href":"https:\/\/odanlab.com\/fr\/wp-json\/wp\/v2\/pages\/1525","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/odanlab.com\/fr\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/odanlab.com\/fr\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/odanlab.com\/fr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/odanlab.com\/fr\/wp-json\/wp\/v2\/comments?post=1525"}],"version-history":[{"count":7,"href":"https:\/\/odanlab.com\/fr\/wp-json\/wp\/v2\/pages\/1525\/revisions"}],"predecessor-version":[{"id":1798,"href":"https:\/\/odanlab.com\/fr\/wp-json\/wp\/v2\/pages\/1525\/revisions\/1798"}],"wp:attachment":[{"href":"https:\/\/odanlab.com\/fr\/wp-json\/wp\/v2\/media?parent=1525"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}